At the Jardines del Kelito stadium, Tembetary, from the Primera B, triumphed 1-0 against Celeste de la Chacarita, from the First Division, thanks to a goal from Justo Roa.
The red-and-green team will have as rival in the next round the winner of the key between Rubio Ñu and 12 de Octubre de Itauguá, who face each other on Thursday (4:00 p.m.).
On the other hand, Guaireña FC triumphed with a 5-0 win against General Caballero de Zeballos Cué.
Cristhian Ocampos with a brace, Milton Maciel, Francisco Brizueña and Víctor Ayala scored the goals at the Parque del Guairá stadium.
The Albiceleste de Villarrica will face the winner between Benjamín Aceval and Sportivo Ameliano in the round of the eight best (Thursday, 18:30).
The entrance Tembetary surprises Resistencia, Guaireña thrashes heading to quarterfinals was first published in diary TODAY.