A study International has first identified new factors genetic of risk For the depression In the main populations of the world, a investigation of international impact that allows scientists to predict risk to suffer depressionregardless of ethnic origin.
It is the older and more diverse study genetic performed on the depressiona investigation In which experts from the University of Granada participate (UGR), In southern Spain, which has revealed almost 300 links genetic With this disease unknown so far.
According to the work, one hundred of the new variations genetic Discovered – pequeñas differences in the DNA sequence that composes a gene – were identified thanks to the inclusion of people of African ancestry, oriental, Hispanic and sudasiatics.
Previous investigations on the genetics of the depression They have focused mainly on white populations descendants of Europeans, which has led to therapies developed with approaches genetic They may not be effective in other ethnicities, which increases existing sanitary inequalities.
The researchers of the Federico Olóriz Neuroscience Institute of the UGR and of the Biosanitary Institute of Granada (IBS.Granada) Jorge Cervilla, Blanca Gutiérrez, Margarita Rivera and Esther Molina have participated in this scientific finding.
The team of researchers has been able to predict more accurately the risk of depression of a person taking into account the new identified variants.
He studydirected by the University of Edinburgh and the King’s College in London, has analyzed data genetic anonymous of more than five million people from 29 countries around the world, with one in four individuals included in the study of non -European descent.
The authors have identified a total of 700 variations In the code genetic of individuals related to the development of depressionalmost half of which had never been associated with this disease before, and involved 308 genes Specific.
According to experts, the results offer a new perspective on the impact of the depression in the brain and present possible new targets for their treatmentespecially with the use of pregabaline and fashion drugs.
In the team of investigation The psychiatric genomics consortium have participated scientists from all continents, including studies in South Africa, Brazil, Mexico, the United States, Australia, Taiwan and China.
“There are huge lagoons in our understanding of the depression Clinic that limit opportunities to improve the results for those affected. It is essential to carry out broader and more representative studies from all over the world to obtain the necessary information to develop new and better therapies, “summarized the co -director of the studyAndrew Mcintosh, from the University of Edinburgh.
