The new work discovered that, after suffering from the infection, the probabilities of suffering from this disease rise between 3% and 5%. It is even higher among men and those who have experienced a serious illness.
infection by SARS-CoV-2 May cause aftermath acute and chronic. Now that the most critical phase of the pandemic is in the past, scientists can gain perspective on the consequences for the health of those who have experienced the disease.
The new research, published in JAMA Network Open, suggests that infection COVID-19 is related to a risk significantly greater than diabetesand may have contributed to a excess burden of this ailment between 3% and 5% of the population.
Our team of specialists from the University of British Columbia in Canada also found a higher incidence of diabetes among men than among women, and among those with severe disease compared with those without COVID-19.
These findings suggest that this infection may continue to be associated with outcomes in organ systems involved in blood glucose regulation in the post-acute phase and therefore may have contributed to the 3% to 5% of excess incident diabetes cases found in this study.
The population-based cohort study was conducted between January 1, 2020, and December 31, 2021. The British Columbia COVID-19 Cohort was used, a surveillance platform that integrates infection data with other registries based on in the population. The study included a total of 629,935 people who were tested for SARS-CoV-2 using real-time reverse transcription polymerase chain reaction (RT-PCR).
Those who tested positive were matched with individuals who tested negative based on sex, age, and date of test collection in a 1:4 ratio. The analysis was performed from January 14, 2022 to January 19, 2023.
detect the consequences
The primary objective of the study was to identify incident cases of diabetes that occurred more than 30 days after the sample collection date for the SARS-CoV-2 test.
Identification was made using a validated algorithm based on medical visits, hospitalization and chronic disease records, as well as prescription medications for diabetes control. Of the entire cohort, the median age (IQR) was 32 (25.0-42.0) years, with 51.2% of the cohort being women.
Of this group, 125,987 people were exposed to SARS-CoV-2 and 503,948 were not.
During the 257-day follow-up period, incident diabetes events were observed in 608 people who were exposed (0.5%) and 1864 people who were not (0.4%). The incidence rate of diabetes was significantly higher in the exposed group, with 672.2 incidents, compared to the non-exposed group, with an average 508.7 incidents.
Using these data, the risk of incident diabetes was found to be a 17% greater in the exposed group than in the other and a 22% greater between men than women. It was also higher among people with severe illness from COVID-19, including people admitted to the intensive care unit or hospital.
The fraction of incident diabetes cases attributable to SARS-CoV-2 infection was 3.41% overall and 4.75% among men, this could potentially be due to immune responses Sex-specific, such as higher serum SARS-CoV-2 IgG antibody concentrations in female patients compared to male patients.
However, when restricted the sample to people hospitalized for COVID-19 and admitted to the ICU, not only an increase in risk was observed between the groups of greater severity, but also significant associations between male and female patients.
Our study highlights the importance of health agencies and physicians being aware of potential long term consequences of COVID-19 and monitor people after COVID-19 infection for new-onset diabetes for timely diagnosis and treatment.
