The fires raised thick clouds of smoke as the flames burned just meters from homes, forcing people to flee as others tried to protect their homes.
Greece was facing the first day of a heat wave on Saturday that should last ten days. Temperatures could reach 42º in some regions.
The fire on Lesbos broke out at 10:00 a.m. local time (0700 GMT) on Saturday and is burning on two fronts, one heading towards the town of Vrisa and the other inside Vatera.
Police said 450 people were evacuated from two hotels and 92 houses in Vatera.
The Greek coast guard had previously said it had evacuated nine people, including five foreigners, from a beach in Vatera.
Firefighters also deployed seven firefighting planes and a helicopter to fight the flames.
On the other hand, firefighters were still fighting a forest fire for the third day on Saturday in another part of Greece, the Dadia National Park, known for its colony of black vultures and located in the northeastern region of Evros.
The entrance Hundreds of evacuees on the Greek island of Lesbos due to a fire was first published in diary TODAY.
